PF3D7_0822800 (SNRNP40)

Genome location: Pf3D7_08_v3:1,005,414..1,007,397(+)

Genome classification: Core

Function and Localization

Product Description: U5 small nuclear ribonucleoprotein 40 kDa protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0071013	catalytic step 2 spliceosome
Component	GO:0005732	sno(s)RNA-containing ribonucleoprotein complex
Function	GO:0003723	RNA binding
Process	GO:0000375	RNA splicing, via transesterification reactions

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.36	0.82
Trophozoite	expressed	0.38	0.76
Schizont	expressed	0.08	0.94
Gametocyte	expressed	0.26	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0822800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.738 | MFS: -2.605 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4X1

"Best" AlphaFill ligand hit: SIW (keggin (sta), Local RMSD=0.05) with 6Y7O (Global RMSD=7.28)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102288

Most Similar Human Ortholog: Q96DI7

TM-align score: 0.92 | RMSD: 1.64

Seq Identity: 0.34 | Length: 310 / 324

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000060688	small nuclear ribonucleoprotein U5 subunit 40

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	11	8	17
disruptive	3	32	21	51
missense	3	32	21	46

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	22	14	26
disruptive	7	73	41	80
missense	7	67	38	51

PlasmoDB Total SNPs: 108

Non-coding: 99 | Synonymous: 4 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 324 | Molecular Weight (kDa): 37.086

UniProt ID(s): C0H4X1

PDB ID(s): None

Isoelectric Point: 5.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR019775	WD40 repeat, conserved site
InterPro	IPR020472	G-protein beta WD-40 repeat
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	PF00400	WD40 repeat
Superfamily	SSF50978	WD40-repeat-containing domain superfamily