Genome location: Pf3D7_08_v3:1,006,504..1,011,755(-)
Genome classification: Core
Product Description: PhIL1-interacting candidate PIC2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070258 | inner membrane pellicle complex |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.36 | 0.87 |
| Trophozoite | not expressed | 0.12 | 0.93 |
| Schizont | expressed | 1.67 | 0.53 |
| Gametocyte | not expressed | 0.06 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0822900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.989 | MFS: -2.578 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0707700)
Modification: Tagged | RMgm-4556
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IB63
"Best" AlphaFill ligand hit: NUP (, Local RMSD=0.03) with 2Q8Z (Global RMSD=23.02)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 46 | 30 | 61 |
| disruptive | 64 | 167 | 95 | 199 |
| missense | 46 | 144 | 88 | 154 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 92 | 47 | 67 |
| disruptive | 114 | 322 | 132 | 277 |
| missense | 74 | 267 | 101 | 185 |
PlasmoDB Total SNPs: 327
Non-coding: 103 | Synonymous: 120 | Nonsynonymous: 104 | Stop Codon: 0
Protein Length: 1176 | Molecular Weight (kDa): 138.242
UniProt ID(s): Q8IB63
PDB ID(s): None
Isoelectric Point: 5.01
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 33830607 | Identification of novel inner membrane complex and apical annuli proteins of themalaria parasite Plasmodium falciparum. | Wichers JS, Wunderlich J, ..., Gilberger TW | 10.1111/cmi.13341 |
| 26763345 | Overlap of copper and iron uptake systems in mitochondria in Saccharomycescerevisiae | Vest KE, Wang J, ..., Cobine PA | 10.1098/rsob.150223 |
| 23846699 | Copper import into the mitochondrial matrix in Saccharomyces cerevisiae ismediated by Pic2, a mitochondrial carrier family protein | Vest KE, Leary SC, Winge DR, Cobine PA | 10.1074/jbc.M113.470674 |