PF3D7_0823100

Genome location: Pf3D7_08_v3:1,018,071..1,021,346(-)

Genome classification: Core

Function and Localization

Product Description: RWD domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005844	polysome
Process	GO:0002181	cytoplasmic translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.24	0.88
Trophozoite	not expressed	0.26	0.85
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.10	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0823100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.01 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4X2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102929

Most Similar Human Ortholog: Q9H446

TM-align score: 0.52 | RMSD: 3.18

Seq Identity: 0.28 | Length: 137 / 229

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000111832	RWD domain containing 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	2
missense	0	0	0	0

PlasmoDB Total SNPs: 161

Non-coding: 147 | Synonymous: 7 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 229 | Molecular Weight (kDa): 27.395

UniProt ID(s): C0H4X2

PDB ID(s): None

Isoelectric Point: 4.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006575	RWD domain
InterPro	IPR016135	Ubiquitin-conjugating enzyme/RWD-like
InterPro	IPR040213	GIR2-like
PFam	PF05773	RWD domain
Superfamily	SSF54495	Ubiquitin-conjugating enzyme/RWD-like