PF3D7_0823400

Genome location: Pf3D7_08_v3:1,034,417..1,036,428(+)

Genome classification: Core

Function and Localization

Product Description: alpha/beta hydrolase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0823400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.889 | MFS: -2.915 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4X3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105308

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	26	22	31
disruptive	3	26	13	59
missense	3	26	12	58

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	63	25	25
disruptive	9	60	49	98
missense	6	47	41	67

PlasmoDB Total SNPs: 68

Non-coding: 43 | Synonymous: 20 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 494 | Molecular Weight (kDa): 58.637

UniProt ID(s): C0H4X3

PDB ID(s): None

Isoelectric Point: 8.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR029058	Alpha/Beta hydrolase fold
PFam	N/A	N/A
Superfamily	SSF53474	Alpha/Beta hydrolase fold