Genome location: Pf3D7_08_v3:1,036,973..1,038,764(-)
Genome classification: Core
Product Description: inner membrane complex protein 1i, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070258 | inner membrane pellicle complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | not expressed | 0.04 | 0.98 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.23 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0823500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.496 | MFS: -2.483 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0707100)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0707400)
Modification: Tagged | RMgm-4493
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IB69
"Best" AlphaFill ligand hit: GDS (oxidized glutathione disulfide, Local RMSD=3.19) with 3FR3 (Global RMSD=46.02)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 28 | 15 | 37 |
| disruptive | 9 | 50 | 18 | 53 |
| missense | 9 | 49 | 18 | 52 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 58 | 17 | 41 |
| disruptive | 17 | 89 | 46 | 83 |
| missense | 17 | 80 | 40 | 69 |
PlasmoDB Total SNPs: 66
Non-coding: 43 | Synonymous: 13 | Nonsynonymous: 9 | Stop Codon: 1
Protein Length: 502 | Molecular Weight (kDa): 58.205
UniProt ID(s): Q8IB69
PDB ID(s): None
Isoelectric Point: 6.61
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR022086 | Inner membrane complex protein |
| PFam | PF12314 | Inner membrane complex protein |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 26018192 | Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-FamilyTranscription Factor. | Kaneko I, Iwanaga S, ..., Yuda M | 10.1371/journal.ppat.1004905 |
| 34395314 | Calcium in the Backstage of Malaria Parasite Biology | de Oliveira LS, Alborghetti MR, ..., Charneau S | 10.3389/fcimb.2021.708834 |