About Gene List

PF3D7_0823700 (TOM7)

Genome location: Pf3D7_08_v3:1,041,365..1,042,613(-)

Genome classification: Core

Function and Localization

Product Description: mitochondrial import receptor subunit TOM7, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005742 mitochondrial outer membrane translocase complex
Component GO:0005739 mitochondrion
Process GO:0006626 protein targeting to mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.01 1.00
Trophozoite expressed 0.02 0.99
Schizont not expressed 0.00 1.00
Gametocyte not expressed 0.01 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0823700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.165 | MFS: -0.727 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0706900)

  • Relative Growth Rate: 1.02 ± 0.13
  • Confidence: 5.50

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0706900)

Modification: Disrupted | RMgm-2200

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB71

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179336

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 96

Non-coding: 86 | Synonymous: 9 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 66 | Molecular Weight (kDa): 7.913

UniProt ID(s): Q8IB71

PDB ID(s): None

Isoelectric Point: 9.6

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
21705432 Localization of mRNAs coding for mitochondrial proteins in the yeastSaccharomyces cerevisiae Gadir N, Haim-Vilmovsky L, Kraut-Cohen J, Gerst JE 10.1261/rna.2621111
27458014 The Import of Proteins into the Mitochondrion of Toxoplasma gondii van Dooren GG, Yeoh LM, Striepen B, McFadden GI 10.1074/jbc.M116.725069
23276920 The power of yeast to model diseases of the powerhouse of the cell Baile MG, Claypool SM 10.2741/4098