Product Description: DnaJ protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0020020 | food vacuole |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0051085 | chaperone cofactor-dependent protein refolding |
| Process | GO:0042026 | protein refolding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.17 | 0.92 |
| Trophozoite | expressed | 0.61 | 0.65 |
| Schizont | expressed | 0.34 | 0.79 |
| Gametocyte | not expressed | 0.22 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0823800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.17 | MFS: -3.258 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0706800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0706800)
Modification: Disrupted | RMgm-2199
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IB72
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 34 | 14 | 37 |
| disruptive | 14 | 57 | 36 | 88 |
| missense | 14 | 56 | 36 | 82 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 64 | 21 | 37 |
| disruptive | 28 | 109 | 72 | 125 |
| missense | 25 | 101 | 67 | 99 |
PlasmoDB Total SNPs: 157
Non-coding: 112 | Synonymous: 28 | Nonsynonymous: 17 | Stop Codon: 0
Protein Length: 655 | Molecular Weight (kDa): 76.682
UniProt ID(s): Q8IB72
PDB ID(s): None
Isoelectric Point: 9.67
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001623 | DnaJ domain |
| InterPro | IPR013766 | Thioredoxin domain |
| InterPro | IPR017964 | DNA-directed DNA polymerase, family B, conserved site |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| InterPro | IPR036869 | Chaperone J-domain superfamily |
| PFam | PF00085 | Thioredoxin domain |
| PFam | PF00226 | DnaJ domain |
| Superfamily | SSF46565 | Chaperone J-domain superfamily |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |