Genome location: Pf3D7_08_v3:1,047,155..1,048,908(+)
Genome classification: Core
Product Description: dicarboxylate/tricarboxylate carrier
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005743 | mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0005310 | dicarboxylic acid transmembrane transporter activity |
| Function | GO:0015367 | oxoglutarate:malate antiporter activity |
| Process | GO:0015742 | alpha-ketoglutarate transport |
| Process | GO:0006835 | dicarboxylic acid transport |
| Process | GO:0015743 | malate transport |
| Process | GO:0006839 | mitochondrial transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.18 | 0.88 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | expressed | 0.10 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0823900
Resistome Missense Mutations: Q60H
Resistome Compounds with Missense Mutations: Bortezomib
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.162 | MFS: -2.799 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IB73
"Best" AlphaFill ligand hit: CXT (carboxyatractyloside, Local RMSD=1.41) with 1OKC (Global RMSD=3.02)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101430
Most Similar Human Ortholog: Q02978
TM-align score: 0.87 | RMSD: 2.16
Seq Identity: 0.38 | Length: 294 / 318
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000108528 | solute carrier family 25 member 11 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 20 | 8 | 16 |
| disruptive | 2 | 14 | 14 | 17 |
| missense | 2 | 14 | 14 | 15 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 32 | 14 | 23 |
| disruptive | 4 | 37 | 20 | 57 |
| missense | 4 | 31 | 17 | 39 |
PlasmoDB Total SNPs: 83
Non-coding: 71 | Synonymous: 9 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 318 | Molecular Weight (kDa): 35.387
UniProt ID(s): Q8IB73
PDB ID(s): None
Isoelectric Point: 10.06
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR018108 | Mitochondrial substrate/solute carrier |
| InterPro | IPR023395 | Mitochondrial carrier domain superfamily |
| PFam | PF00153 | Mitochondrial substrate/solute carrier |
| Superfamily | SSF103506 | Mitochondrial carrier domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 21986531 | Cell-free synthesis, reconstitution, and characterization of a mitochondrialdicarboxylate-tricarboxylate carrier of Plasmodium falciparum. | Nozawa A, Fujimoto R, ..., Tozawa Y | 10.1016/j.bbrc.2011.09.130 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |