PF3D7_0824000

Genome location: Pf3D7_08_v3:1,049,233..1,051,936(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	not expressed	0.09	0.95
Schizont	not expressed	0.03	0.98
Gametocyte	possibly expressed	0.16	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0824000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.181 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0706600)

Modification: Disrupted | RMgm-2198

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB74

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532909

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	40	28	50
disruptive	27	122	70	153
missense	18	119	66	137

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	78	40	50
disruptive	56	268	99	185
missense	36	234	89	141

PlasmoDB Total SNPs: 106

Non-coding: 7 | Synonymous: 48 | Nonsynonymous: 51 | Stop Codon: 0

Protein Information

Protein Length: 807 | Molecular Weight (kDa): 95.821

UniProt ID(s): Q8IB74

PDB ID(s): None

Isoelectric Point: 10.2

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A