PF3D7_0824200

Genome location: Pf3D7_08_v3:1,054,798..1,059,140(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.10	0.95
Trophozoite	expressed	0.70	0.61
Schizont	expressed	0.08	0.95
Gametocyte	expressed	0.42	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0824200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.016 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0706400)

Relative Growth Rate: 0.03 ± 0.03
Confidence: 8.54

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0706400)

Modification: Disrupted | RMgm-4147

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4X4

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=5.82) with 6JWY (Global RMSD=21.60)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533253

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	49	23	63
disruptive	31	130	65	155
missense	20	94	51	134

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	105	37	67
disruptive	57	270	143	296
missense	35	190	114	194

PlasmoDB Total SNPs: 189

Non-coding: 83 | Synonymous: 73 | Nonsynonymous: 33 | Stop Codon: 0

Protein Information

Protein Length: 1124 | Molecular Weight (kDa): 133.806

UniProt ID(s): C0H4X4

PDB ID(s): None

Isoelectric Point: 5.8

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A