Genome location: Pf3D7_08_v3:1,059,246..1,061,567(-)
Genome classification: Core
Product Description: GTP-binding protein Obg2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0005525 | GTP binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.38 | 0.77 |
| Schizont | expressed | 0.41 | 0.74 |
| Gametocyte | expressed | 0.52 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0824300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.017 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0706300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0706300)
Modification: Disrupted | RMgm-2195
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IB77
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.37) with 2E87 (Global RMSD=5.11)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 35 | 9 | 32 |
| disruptive | 14 | 63 | 43 | 84 |
| missense | 14 | 62 | 43 | 76 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 58 | 26 | 48 |
| disruptive | 24 | 148 | 85 | 170 |
| missense | 21 | 128 | 74 | 128 |
PlasmoDB Total SNPs: 58
Non-coding: 1 | Synonymous: 32 | Nonsynonymous: 25 | Stop Codon: 0
Protein Length: 773 | Molecular Weight (kDa): 91.194
UniProt ID(s): Q8IB77
PDB ID(s): None
Isoelectric Point: 9.61
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006073 | GTP binding domain |
| InterPro | IPR006169 | GTP1/OBG domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR036726 | GTP1/OBG domain superfamily |
| PFam | PF01018 | GTP1/OBG domain |
| PFam | PF01926 | GTP binding domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF82051 | GTP1/OBG domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 29642957 | Characterization of mitochondrion-targeted GTPases in Plasmodium falciparum. | Gupta K, Gupta A, Haider A, Habib S | 10.1017/S0031182018000501 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |