Genome location: Pf3D7_08_v3:1,062,190..1,065,384(-)
Genome classification: Core
Product Description: nucleoside transporter 2
SignalP Peptide: N/A
# Transmembrane Domains: 10
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0016020 | membrane |
| Function | GO:0005337 | nucleoside transmembrane transporter activity |
| Process | GO:0015858 | nucleoside transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.10 | 0.95 |
| Trophozoite | expressed | 0.66 | 0.63 |
| Schizont | expressed | 0.07 | 0.95 |
| Gametocyte | expressed | 0.21 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0824400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.907 | #Insertions: 5
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0706200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0706200)
Modification: Disrupted | RMgm-2194
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IB78
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 10 | 9 | 21 |
| disruptive | 15 | 18 | 17 | 54 |
| missense | 15 | 18 | 15 | 47 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 19 | 15 | 36 |
| disruptive | 22 | 58 | 36 | 131 |
| missense | 17 | 42 | 33 | 88 |
PlasmoDB Total SNPs: 118
Non-coding: 83 | Synonymous: 20 | Nonsynonymous: 15 | Stop Codon: 0
Protein Length: 585 | Molecular Weight (kDa): 67.642
UniProt ID(s): Q8IB78
PDB ID(s): None
Isoelectric Point: 9.01
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002259 | Equilibrative nucleoside transporter |
| InterPro | IPR036259 | MFS transporter superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF103473 | MFS transporter superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 20439460 | PfNT2, a permease of the equilibrative nucleoside transporter family in theendoplasmic reticulum of Plasmodium falciparum. | Downie MJ, El Bissati K, ..., Ben Mamoun C | 10.1074/jbc.M110.118489 |