PF3D7_0824500

Genome location: Pf3D7_08_v3:1,066,036..1,067,958(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.09	0.96
Trophozoite	no data	0.57	0.67
Schizont	no data	0.06	0.96
Gametocyte	no data	0.40	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0824500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.042 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0706100)

Relative Growth Rate: 0.24 ± 0.14
Confidence: 5.29

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0706100)

Modification: Disrupted | RMgm-2193

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB79

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139471

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	14	9	15
disruptive	10	45	30	65
missense	10	43	27	58

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	28	16	24
disruptive	20	107	48	107
missense	18	90	44	78

PlasmoDB Total SNPs: 108

Non-coding: 74 | Synonymous: 23 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 373 | Molecular Weight (kDa): 45.099

UniProt ID(s): Q8IB79

PDB ID(s): None

Isoelectric Point: 5.52

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A