Genome location: Pf3D7_08_v3:1,068,408..1,070,384(+)
Genome classification: Core
Product Description: Fe-S cluster assembly protein DRE2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Process | GO:0016226 | iron-sulfur cluster assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.34 | 0.83 |
| Trophozoite | expressed | 0.33 | 0.80 |
| Schizont | expressed | 0.07 | 0.95 |
| Gametocyte | expressed | 0.32 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0824600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.129 | MFS: -3.194 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0706000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4X5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102453
Most Similar Human Ortholog: H3BQ23
TM-align score: 0.69 | RMSD: 2.50
Seq Identity: 0.11 | Length: 107 / 266
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000005194 | cytokine induced apoptosis inhibitor 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 16 | 9 | 22 |
| disruptive | 1 | 15 | 11 | 21 |
| missense | 1 | 15 | 11 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 31 | 18 | 9 |
| disruptive | 7 | 32 | 22 | 54 |
| missense | 4 | 27 | 18 | 40 |
PlasmoDB Total SNPs: 67
Non-coding: 60 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 266 | Molecular Weight (kDa): 30.838
UniProt ID(s): C0H4X5
PDB ID(s): None
Isoelectric Point: 5.09
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007785 | Anamorsin |
| PFam | PF05093 | Anamorsin |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 36990255 | Plasmodium Iron-Sulfur [Fe-S] cluster assembly protein Dre2 as a plausible targetof Artemisinin: Mechanistic insights derived in a prokaryotic heterologoussystem | Kirtikumar Bub N, Anand S, ..., Garg S | 10.1016/j.gene.2023.147396 |
| 25040552 | Cytosolic iron-sulphur protein assembly is functionally conserved and essentialin procyclic and bloodstream Trypanosoma brucei | Basu S, Netz DJ, ..., Lukes J | 10.1111/mmi.12706 |
| 27178802 | Regulatory mechanism of the flavoprotein Tah18-dependent nitric oxide synthesisand cell death in yeast | Yoshikawa Y, Nasuno R, ..., Takagi H | 10.1016/j.niox.2016.04.003 |
| 36773733 | Essential mitochondrial role in iron-sulfur cluster assembly of the cytoplasmicisopropylmalate isomerase Leu1 in Saccharomyces cerevisiae | Pandey AK, Pain J, ..., Pain D | 10.1016/j.mito.2023.02.006 |