PF3D7_0824700 (LMF1)

Genome location: Pf3D7_08_v3:1,070,718..1,074,779(+)

Genome classification: Core

Function and Localization

Product Description: lipase maturation factor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 10

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	expressed	0.19	0.87
Schizont	expressed	0.08	0.94
Gametocyte	expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0824700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.351 | #Insertions: 3

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0705900)

Relative Growth Rate: 0.83 ± 0.12
Confidence: 5.57

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0705900)

Modification: Disrupted | RMgm-2191

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8P4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_152391

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	39	16	38
disruptive	15	59	45	88
missense	15	57	42	76

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	72	29	42
disruptive	31	152	63	161
missense	23	125	50	109

PlasmoDB Total SNPs: 243

Non-coding: 209 | Synonymous: 17 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 590 | Molecular Weight (kDa): 71.243

UniProt ID(s): A0A5K1K8P4

PDB ID(s): None

Isoelectric Point: 8.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009613	Lipase maturation factor
PFam	PF06762	Lipase maturation factor
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
36314270	IMC10 and LMF1 mediate mitochondrial morphology through mitochondrion-pelliclecontact sites in Toxoplasma gondii	Oliveira Souza RO, Jacobs KN, ..., Arrizabalaga G	10.1242/jcs.260083