About Gene List

PF3D7_0824700 (LMF1)

Genome location: Pf3D7_08_v3:1,070,718..1,074,779(+)

Genome classification: Core

Function and Localization

Product Description: lipase maturation factor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 10

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.02 0.99
Trophozoite expressed 0.19 0.87
Schizont expressed 0.08 0.94
Gametocyte expressed 0.11 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0824700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.351 | #Insertions: 3

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0705900)

  • Relative Growth Rate: 0.83 ± 0.12
  • Confidence: 5.57

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0705900)

Modification: Disrupted | RMgm-2191

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8P4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_152391

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 39 16 38
disruptive 15 59 45 88
missense 15 57 42 76

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 72 29 42
disruptive 31 152 63 161
missense 23 125 50 109

PlasmoDB Total SNPs: 243

Non-coding: 209 | Synonymous: 17 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 590 | Molecular Weight (kDa): 71.243

UniProt ID(s): A0A5K1K8P4

PDB ID(s): None

Isoelectric Point: 8.5

Protein Domain Annotations:

Source Family ID Description
InterPro IPR009613 Lipase maturation factor
PFam PF06762 Lipase maturation factor
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
36314270 IMC10 and LMF1 mediate mitochondrial morphology through mitochondrion-pelliclecontact sites in Toxoplasma gondii Oliveira Souza RO, Jacobs KN, ..., Arrizabalaga G 10.1242/jcs.260083