Genome location: Pf3D7_08_v3:1,070,718..1,074,779(+)
Genome classification: Core
Product Description: lipase maturation factor, putative
SignalP Peptide: N/A
# Transmembrane Domains: 10
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0016020 | membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | possibly expressed | 0.02 | 0.99 |
Trophozoite | expressed | 0.19 | 0.87 |
Schizont | expressed | 0.08 | 0.94 |
Gametocyte | expressed | 0.11 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0824700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.351 | #Insertions: 3
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0705900)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0705900)
Modification: Disrupted | RMgm-2191
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K8P4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 6 | 39 | 16 | 38 |
disruptive | 15 | 59 | 45 | 88 |
missense | 15 | 57 | 42 | 76 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 10 | 72 | 29 | 42 |
disruptive | 31 | 152 | 63 | 161 |
missense | 23 | 125 | 50 | 109 |
PlasmoDB Total SNPs: 243
Non-coding: 209 | Synonymous: 17 | Nonsynonymous: 17 | Stop Codon: 0
Protein Length: 590 | Molecular Weight (kDa): 71.243
UniProt ID(s): A0A5K1K8P4
PDB ID(s): None
Isoelectric Point: 8.5
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR009613 | Lipase maturation factor |
PFam | PF06762 | Lipase maturation factor |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
36314270 | IMC10 and LMF1 mediate mitochondrial morphology through mitochondrion-pelliclecontact sites in Toxoplasma gondii | Oliveira Souza RO, Jacobs KN, ..., Arrizabalaga G | 10.1242/jcs.260083 |