PF3D7_0824800

Genome location: Pf3D7_08_v3:1,075,261..1,080,181(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005667	transcription regulator complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.75	0.65
Trophozoite	expressed	0.97	0.49
Schizont	expressed	0.47	0.71
Gametocyte	expressed	0.69	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0824800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -3.008 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB82

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532671

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	60	22	66
disruptive	37	179	92	251
missense	29	152	85	208

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	19	113	46	99
disruptive	84	414	180	401
missense	54	342	142	259

PlasmoDB Total SNPs: 195

Non-coding: 91 | Synonymous: 51 | Nonsynonymous: 53 | Stop Codon: 0

Protein Information

Protein Length: 1276 | Molecular Weight (kDa): 154.869

UniProt ID(s): Q86BT0, Q8IB82

PDB ID(s): None

Isoelectric Point: 9.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A