PF3D7_0824900

Genome location: Pf3D7_08_v3:1,079,441..1,083,413(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.55	0.73
Trophozoite	expressed	0.44	0.76
Schizont	not expressed	0.11	0.93
Gametocyte	not expressed	0.39	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0824900

Resistome Missense Mutations: D785E

Resistome Compounds with Missense Mutations: MMV688533

Resistome # Samples with Disruptive Mutations: 2 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.16 | MFS: -3.265 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0705700)

Relative Growth Rate: 0.83 ± 0.14
Confidence: 5.35

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0705700)

Modification: Disrupted | RMgm-2190

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB83

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532549

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	17	51	34	63
disruptive	34	165	103	230
missense	31	158	95	211

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	24	106	48	64
disruptive	72	357	174	276
missense	59	322	150	213

PlasmoDB Total SNPs: 112

Non-coding: 20 | Synonymous: 61 | Nonsynonymous: 31 | Stop Codon: 0

Protein Information

Protein Length: 978 | Molecular Weight (kDa): 117.081

UniProt ID(s): Q8IB83

PDB ID(s): None

Isoelectric Point: 9.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A