PF3D7_0825100

Genome location: Pf3D7_08_v3:1,091,998..1,093,221(+)

Genome classification: Core

Function and Localization

Product Description: ankyrin-repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	possibly expressed	0.18	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0825100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.924 | MFS: -1.725 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0705500)

Relative Growth Rate: 1.04 ± 0.15
Confidence: 5.20

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0705500)

Modification: Disrupted | RMgm-2188

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB85

"Best" AlphaFill ligand hit: TAR (d(-)-tartaric acid, Local RMSD=2.04) with 6MOJ (Global RMSD=1.71)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_174303

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	5	14
disruptive	0	9	12	19
missense	0	8	12	16

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	24	8	15
disruptive	1	34	24	60
missense	0	29	21	48

PlasmoDB Total SNPs: 83

Non-coding: 77 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 186 | Molecular Weight (kDa): 21.881

UniProt ID(s): Q8IB85

PDB ID(s): None

Isoelectric Point: 8.14

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR036770	Ankyrin repeat-containing domain superfamily
PFam	PF12796	Ankyrin repeat-containing domain
Superfamily	SSF48403	Ankyrin repeat-containing domain superfamily