PF3D7_0825200 (IF3a)

Genome location: Pf3D7_08_v3:1,093,439..1,094,936(+)

Genome classification: Core

Function and Localization

Product Description: translation initiation factor IF-3

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion
Function	GO:0043022	ribosome binding
Function	GO:0003743	translation initiation factor activity
Process	GO:0032790	ribosome disassembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	possibly expressed	0.11	0.92
Schizont	expressed	0.07	0.95
Gametocyte	possibly expressed	0.17	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0825200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.348 | MFS: -3.47 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB86

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102124

Most Similar Human Ortholog: Q9H2K0

TM-align score: 0.53 | RMSD: 4.01

Seq Identity: 0.13 | Length: 124 / 165

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000122033	mitochondrial translational initiation factor 3

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	7	12
disruptive	1	9	8	23
missense	1	9	8	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	22	12	9
disruptive	2	31	14	47
missense	1	25	13	35

PlasmoDB Total SNPs: 64

Non-coding: 57 | Synonymous: 4 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 165 | Molecular Weight (kDa): 19.555

UniProt ID(s): Q8IB86

PDB ID(s): None

Isoelectric Point: 10.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001288	Translation initiation factor 3
InterPro	IPR019815	Translation initiation factor 3, C-terminal
InterPro	IPR036788	Translation initiation factor 3 (IF-3), C-terminal domain superfamily
PFam	PF00707	Translation initiation factor 3, C-terminal
Superfamily	SSF55200	Translation initiation factor 3 (IF-3), C-terminal domain superfamily