PF3D7_0825300

Genome location: Pf3D7_08_v3:1,094,794..1,095,972(-)

Genome classification: Core

Function and Localization

Product Description: SAYSvFN domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.05	0.97
Trophozoite	not expressed	0.19	0.87
Schizont	not expressed	0.09	0.93
Gametocyte	expressed	0.45	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0825300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.258 | MFS: -3.275 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB87

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_121103

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	8	1	13
disruptive	0	8	3	22
missense	0	8	3	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	16	10	13
disruptive	3	27	18	59
missense	1	21	15	40

PlasmoDB Total SNPs: 60

Non-coding: 48 | Synonymous: 12 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 148 | Molecular Weight (kDa): 17.205

UniProt ID(s): Q8IB87

PDB ID(s): None

Isoelectric Point: 10.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004027	SEC-C motif
InterPro	IPR019387	Uncharacterised domain SAYSvFN
InterPro	IPR039159	SAYSvFN domain-containing protein 1
PFam	PF02810	SEC-C motif
PFam	PF10260	Uncharacterised domain SAYSvFN
Superfamily	SSF103642	N/A