Genome location: Pf3D7_08_v3:1,097,742..1,100,613(+)
Genome classification: Core
Product Description: protein KRI1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030686 | 90S preribosome |
| Component | GO:0005730 | nucleolus |
| Process | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.04 | 0.55 |
| Trophozoite | expressed | 0.58 | 0.68 |
| Schizont | expressed | 0.16 | 0.91 |
| Gametocyte | expressed | 0.74 | 0.60 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0825500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.205 | MFS: -2.723 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0705100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IB88
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103057
Most Similar Human Ortholog: H0YG91
TM-align score: 0.31 | RMSD: 4.61
Seq Identity: 0.09 | Length: 56 / 630
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000129347 | KRI1 homolog |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 32 | 16 | 36 |
| disruptive | 16 | 95 | 56 | 145 |
| missense | 6 | 92 | 45 | 121 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 63 | 23 | 48 |
| disruptive | 30 | 250 | 96 | 215 |
| missense | 15 | 198 | 70 | 128 |
PlasmoDB Total SNPs: 128
Non-coding: 63 | Synonymous: 31 | Nonsynonymous: 34 | Stop Codon: 0
Protein Length: 630 | Molecular Weight (kDa): 75.292
UniProt ID(s): Q8IB88
PDB ID(s): None
Isoelectric Point: 4.96
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR018034 | KRR1 interacting protein 1 |
| InterPro | IPR024626 | Kri1-like, C-terminal |
| PFam | PF12936 | Kri1-like, C-terminal |
| Superfamily | SSF57850 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 24990943 | Interaction between ribosome assembly factors Krr1 and Faf1 is essential forformation of small ribosomal subunit in yeast | Zheng S, Lan P, Liu X, Ye K | 10.1074/jbc.M114.584490 |