PF3D7_0825600 (COA5)

Genome location: Pf3D7_08_v3:1,100,637..1,101,453(-)

Genome classification: Core

Function and Localization

Product Description: cytochrome c oxidase assembly factor 5, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0033617	mitochondrial cytochrome c oxidase assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	expressed	0.13	0.91
Schizont	expressed	0.03	0.98
Gametocyte	expressed	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0825600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.204 | MFS: -2.879 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB89

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104546

Most Similar Human Ortholog: Q86WW8

TM-align score: 0.61 | RMSD: 2.53

Seq Identity: 0.24 | Length: 55 / 85

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000183513	cytochrome c oxidase assembly factor 5

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	1	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	1	0	0
disruptive	0	0	0	0
missense	0	0	0	0

PlasmoDB Total SNPs: 45

Non-coding: 43 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 85 | Molecular Weight (kDa): 9.88

UniProt ID(s): Q8IB89

PDB ID(s): None

Isoelectric Point: 9.36

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR018793	Cytochrome c oxidase assembly protein PET191
PFam	PF10203	Cytochrome c oxidase assembly protein PET191
Superfamily	N/A	N/A