PF3D7_0825700 (CryPH)

Genome location: Pf3D7_08_v3:1,101,887..1,102,804(-)

Genome classification: Core

Function and Localization

Product Description: crystalloid-specific PH domain-containing protein, putative

SignalP Peptide: MRNIIFLFCLILFLVCFCQG

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0044312	crystalloid
Component	GO:0005737	cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.01	0.99
Gametocyte	expressed	1.44	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0825700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.991 | MFS: -2.392 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0704900)

Relative Growth Rate: 1.03 ± 0.13
Confidence: 5.50

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0704900)

Modification: Tagged | RMgm-4861

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB90

"Best" AlphaFill ligand hit: HEM (heme, Local RMSD=0.21) with 7OW9 (Global RMSD=17.89)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156435

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	7	8	22
disruptive	13	41	21	57
missense	13	41	20	53

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	19	17	19
disruptive	19	85	35	80
missense	17	78	32	63

PlasmoDB Total SNPs: 26

Non-coding: 1 | Synonymous: 6 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 305 | Molecular Weight (kDa): 36.067

UniProt ID(s): Q8IB90

PDB ID(s): None

Isoelectric Point: 5.85

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF50729	N/A