PF3D7_0825800

Genome location: Pf3D7_08_v3:1,103,768..1,105,108(+)

Genome classification: Core

Function and Localization

Product Description: PH-like domain-containing protein, putative

SignalP Peptide: MKGRQSLSFLLLSVPYFFLFLWNEDIKC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0044312	crystalloid

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.05	0.97
Schizont	possibly expressed	0.02	0.99
Gametocyte	expressed	1.46	0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0825800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -2.936 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0704800)

Modification: Tagged | RMgm-4863

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4X9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146166

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	27	7	35
disruptive	7	48	35	74
missense	7	48	34	70

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	46	15	35
disruptive	15	119	55	115
missense	10	112	51	90

PlasmoDB Total SNPs: 35

Non-coding: 0 | Synonymous: 18 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 446 | Molecular Weight (kDa): 52.127

UniProt ID(s): C0H4X9

PDB ID(s): None

Isoelectric Point: 7.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A