PF3D7_0826000

Genome location: Pf3D7_08_v3:1,108,918..1,112,872(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	not expressed	0.35	0.81
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.33	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0826000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -3.062 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0704600)

Relative Growth Rate: 0.10 ± 0.09
Confidence: 6.11

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB93

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_133999

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	62	34	62
disruptive	45	214	106	252
missense	30	159	90	204

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	29	115	42	59
disruptive	95	458	175	365
missense	55	338	136	211

PlasmoDB Total SNPs: 239

Non-coding: 38 | Synonymous: 119 | Nonsynonymous: 82 | Stop Codon: 0

Protein Information

Protein Length: 1172 | Molecular Weight (kDa): 138.331

UniProt ID(s): Q8IB93

PDB ID(s): None

Isoelectric Point: 9.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A