PF3D7_0826200

Genome location: Pf3D7_08_v3:1,142,499..1,144,972(-)

Genome classification: Core

Function and Localization

Product Description: alpha/beta hydrolase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0016787	hydrolase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.06	0.96
Schizont	not expressed	0.15	0.89
Gametocyte	not expressed	0.60	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0826200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.022 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0704400)

Relative Growth Rate: 1.01 ± 0.06
Confidence: 6.89

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0704400)

Modification: Disrupted | RMgm-2182

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB95

"Best" AlphaFill ligand hit: PPI (propanoic acid, Local RMSD=0.23) with 1A8S (Global RMSD=4.36)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_129556

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	30	17	57
disruptive	17	78	47	101
missense	11	61	34	86

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	66	35	58
disruptive	46	174	87	158
missense	22	129	72	111

PlasmoDB Total SNPs: 87

Non-coding: 24 | Synonymous: 38 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 602 | Molecular Weight (kDa): 70.695

UniProt ID(s): Q8IB95

PDB ID(s): None

Isoelectric Point: 10.07

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022742	Serine aminopeptidase, S33
InterPro	IPR029058	Alpha/Beta hydrolase fold
PFam	PF12146	Serine aminopeptidase, S33
Superfamily	SSF53474	Alpha/Beta hydrolase fold