PF3D7_0826300

Genome location: Pf3D7_08_v3:1,144,934..1,147,897(+)

Genome classification: Core

Function and Localization

Product Description: SPRY domain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0048188	Set1C/COMPASS complex
Function	GO:0000976	transcription cis-regulatory region binding
Process	GO:0051568	histone H3-K4 methylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	expressed	0.30	0.81
Schizont	expressed	0.13	0.90
Gametocyte	expressed	0.29	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0826300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -1.646 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB96

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102272

Most Similar Human Ortholog: Q9UBL3

TM-align score: 0.47 | RMSD: 4.37

Seq Identity: 0.28 | Length: 246 / 445

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000129691	ASH2 like, histone lysine methyltransferase complex subunit

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	26	19	33
disruptive	15	68	34	84
missense	14	68	32	77

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	64	18	26
disruptive	28	141	40	120
missense	24	130	34	87

PlasmoDB Total SNPs: 218

Non-coding: 184 | Synonymous: 21 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 445 | Molecular Weight (kDa): 51.931

UniProt ID(s): Q8IB96

PDB ID(s): None

Isoelectric Point: 8.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003877	SPRY domain
InterPro	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
InterPro	IPR037353	Histone methyltransferase complex subunit ASH2
PFam	PF00622	SPRY domain
Superfamily	SSF49899	Concanavalin A-like lectin/glucanase domain superfamily