PF3D7_0826600 (VAMP7)

Genome location: Pf3D7_08_v3:1,156,860..1,158,860(-)

Genome classification: Core

Function and Localization

Product Description: SNARE protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0006886	intracellular protein transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.05	0.97
Trophozoite	expressed	0.20	0.88
Schizont	expressed	0.11	0.92
Gametocyte	expressed	0.22	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0826600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.508 | MFS: -3.607 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IB99

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_138474

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	12	5	21
disruptive	2	12	6	28
missense	2	12	6	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	27	15	28
disruptive	4	29	31	69
missense	3	23	28	44

PlasmoDB Total SNPs: 62

Non-coding: 53 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 276 | Molecular Weight (kDa): 32.598

UniProt ID(s): Q0ZAF5, Q8IB99

PDB ID(s): None

Isoelectric Point: 8.36

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001388	Synaptobrevin
PFam	PF00957	Synaptobrevin
Superfamily	SSF58038	N/A