Genome location: Pf3D7_08_v3:1,159,770..1,162,786(-)
Genome classification: Core
Product Description: receptor for activated c kinase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0019899 | enzyme binding |
| Function | GO:0005080 | protein kinase C binding |
| Function | GO:0043022 | ribosome binding |
| Process | GO:0001934 | positive regulation of protein phosphorylation |
| Process | GO:0051302 | regulation of cell division |
| Process | GO:0072344 | rescue of stalled ribosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.29 | 0.49 |
| Trophozoite | expressed | 1.49 | 0.36 |
| Schizont | expressed | 0.21 | 0.87 |
| Gametocyte | expressed | 0.52 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0826700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.125 | MFS: -2.934 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBA0
"Best" AlphaFill ligand hit: ALQ (2-methyl-propionic acid, Local RMSD=0.35) with 4GM3 (Global RMSD=2.42)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101640
Most Similar Human Ortholog: D6RFX4
TM-align score: 0.97 | RMSD: 1.03
Seq Identity: 0.66 | Length: 194 / 323
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000204628 | receptor for activated C kinase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 9 | 4 | 1 | 6 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 11 | 8 | 3 | 4 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 223
Non-coding: 217 | Synonymous: 6 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 323 | Molecular Weight (kDa): 35.686
PDB ID(s): None
Isoelectric Point: 6.67
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR020472 | G-protein beta WD-40 repeat |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12821141 | Human malaria parasites display a receptor for activated C kinase ortholog. | Madeira L, DeMarco R, ..., Garcia CR | 10.1016/s0006-291x(03)01074-x |
| 19748487 | The plasmodium receptor for activated C kinase protein inhibits Ca(2+) signalingin mammalian cells. | Sartorello R, Amaya MJ, Nathanson MH, Garcia CR | 10.1016/j.bbrc.2009.09.025 |
| 27732881 | Receptor for Activated C-Kinase 1 (PfRACK1) is required for Plasmodium falciparumintra-erythrocytic proliferation. | Blomqvist K, DiPetrillo C, ..., Dvorin JD | 10.1016/j.molbiopara.2016.10.002 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33608523 | 20S proteasomes secreted by the malaria parasite promote its growth. | Dekel E, Yaffe D, ..., Regev-Rudzki N | 10.1038/s41467-021-21344-8 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 38157925 | Toxoplasma gondii surface antigen 1 (SAG1) interacts in vitro with host cellreceptor for activated C kinase 1 (RACK1) | Wang D, Liu Y, ..., Li B | 10.1016/j.actatropica.2023.107112 |