PF3D7_0826900

Genome location: Pf3D7_08_v3:1,164,491..1,167,540(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.17	0.92
Trophozoite	possibly expressed	0.43	0.75
Schizont	expressed	0.24	0.85
Gametocyte	possibly expressed	0.80	0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0826900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.929 | MFS: -2.811 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4Y1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532647

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	53	25	56
disruptive	29	148	91	174
missense	25	137	87	160

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	90	41	52
disruptive	67	339	110	244
missense	46	301	97	179

PlasmoDB Total SNPs: 164

Non-coding: 80 | Synonymous: 35 | Nonsynonymous: 49 | Stop Codon: 0

Protein Information

Protein Length: 752 | Molecular Weight (kDa): 88.435

UniProt ID(s): C0H4Y1

PDB ID(s): None

Isoelectric Point: 10.36

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A