PF3D7_0827200

Genome location: Pf3D7_08_v3:1,177,310..1,180,324(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.04	0.97
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	0.86	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0827200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.302 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0703500)

Modification: Disrupted | RMgm-2179

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBA4

"Best" AlphaFill ligand hit: 3PG (3-phosphoglyceric acid, Local RMSD=0.10) with 2PAA (Global RMSD=19.58)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533646

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	57	25	68
disruptive	69	228	85	196
missense	43	168	73	149

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	24	118	35	58
disruptive	146	422	147	325
missense	83	302	108	178

PlasmoDB Total SNPs: 203

Non-coding: 0 | Synonymous: 106 | Nonsynonymous: 97 | Stop Codon: 0

Protein Information

Protein Length: 1004 | Molecular Weight (kDa): 118.106

UniProt ID(s): Q25779, Q8IBA4

PDB ID(s): None

Isoelectric Point: 9.64

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A