PF3D7_0827300

Genome location: Pf3D7_08_v3:1,181,264..1,183,916(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.68	0.69
Trophozoite	not expressed	0.62	0.65
Schizont	not expressed	0.13	0.92
Gametocyte	not expressed	0.75	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0827300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.488 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBA5

"Best" AlphaFill ligand hit: UPG (uridine-5'-diphosphate-glucose, Local RMSD=4.60) with 7UBY (Global RMSD=31.64)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139214

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	43	24	58
disruptive	30	115	68	175
missense	23	105	64	156

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	79	32	61
disruptive	55	262	120	259
missense	38	218	103	183

PlasmoDB Total SNPs: 123

Non-coding: 13 | Synonymous: 58 | Nonsynonymous: 51 | Stop Codon: 1

Protein Information

Protein Length: 833 | Molecular Weight (kDa): 100.939

UniProt ID(s): Q8IBA5

PDB ID(s): None

Isoelectric Point: 6.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A