PF3D7_0827400

Genome location: Pf3D7_08_v3:1,184,595..1,185,251(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MRKESFLFFICTLNLLINS

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.03	0.99
Trophozoite	not expressed	0.02	0.99
Schizont	possibly expressed	0.04	0.97
Gametocyte	expressed	0.78	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0827400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.528 | MFS: -2.604 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0703300)

Relative Growth Rate: 0.97 ± 0.15
Confidence: 5.18

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0703300)

Modification: Disrupted | RMgm-2178

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBA6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160733

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	8	4	19
disruptive	1	18	9	33
missense	1	18	8	32

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	22	9	17
disruptive	5	50	22	43
missense	2	41	21	35

PlasmoDB Total SNPs: 20

Non-coding: 0 | Synonymous: 15 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 218 | Molecular Weight (kDa): 26.105

UniProt ID(s): Q8IBA6

PDB ID(s): None

Isoelectric Point: 8.38

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A