Product Description: ribosomal protein L21, apicoplast, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0000311 | plastid large ribosomal subunit |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.08 | 0.96 |
| Trophozoite | expressed | 0.68 | 0.62 |
| Schizont | expressed | 0.45 | 0.73 |
| Gametocyte | expressed | 0.66 | 0.63 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0827500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -2.852 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0703200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4Y5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101040
Most Similar Human Ortholog: F5H3L0
TM-align score: 0.62 | RMSD: 2.59
Seq Identity: 0.03 | Length: 32 / 316
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000197345 | mitochondrial ribosomal protein L21 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 18 | 10 | 21 |
| disruptive | 2 | 15 | 11 | 38 |
| missense | 2 | 12 | 10 | 34 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 29 | 9 | 28 |
| disruptive | 5 | 57 | 19 | 66 |
| missense | 2 | 43 | 17 | 55 |
PlasmoDB Total SNPs: 75
Non-coding: 51 | Synonymous: 17 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 316 | Molecular Weight (kDa): 38.51
UniProt ID(s): C0H4Y5
PDB ID(s): None
Isoelectric Point: 10.33
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001787 | Ribosomal protein L21 |
| InterPro | IPR018258 | Ribosomal protein L21, conserved site |
| InterPro | IPR028909 | Ribosomal protein L21-like |
| InterPro | IPR036164 | L21-like superfamily |
| PFam | PF00829 | Ribosomal protein L21-like |
| Superfamily | SSF141091 | L21-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |