About Gene List

PF3D7_0827600

Genome location: Pf3D7_08_v3:1,187,168..1,193,439(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MIFLILSIILFLLTYECKT

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.11 0.95
Trophozoite expressed 1.06 0.49
Schizont expressed 0.47 0.76
Gametocyte expressed 0.65 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0827600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.134 | MFS: -2.804 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBA8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533677

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 25 96 54 114
disruptive 102 279 154 353
missense 47 217 120 245

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 45 185 72 116
disruptive 173 505 246 444
missense 86 376 177 295

PlasmoDB Total SNPs: 408

Non-coding: 165 | Synonymous: 145 | Nonsynonymous: 96 | Stop Codon: 2

Protein Information

Protein Length: 1684 | Molecular Weight (kDa): 203.428

UniProt ID(s): Q8IBA8

PDB ID(s): None

Isoelectric Point: 5.38

Protein Domain Annotations:

Source Family ID Description
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR022967 RNA-binding domain, S1
PFam N/A N/A
Superfamily SSF50249 Nucleic acid-binding, OB-fold

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895