PF3D7_0827700

Genome location: Pf3D7_08_v3:1,193,847..1,196,678(-)

Genome classification: Core

Function and Localization

Product Description: magnesium transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 9

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane
Process	GO:0015693	magnesium ion transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0827700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.447 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0703300)

Modification: Disrupted | RMgm-4784

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBA9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532913

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	57	15	68
disruptive	58	169	102	205
missense	38	135	87	172

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	95	34	88
disruptive	114	343	102	255
missense	63	291	88	189

PlasmoDB Total SNPs: 113

Non-coding: 0 | Synonymous: 56 | Nonsynonymous: 55 | Stop Codon: 2

Protein Information

Protein Length: 943 | Molecular Weight (kDa): 109.652

UniProt ID(s): Q8IBA9

PDB ID(s): None

Isoelectric Point: 9.95

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008521	Magnesium transporter NIPA
PFam	PF05653	Magnesium transporter NIPA
Superfamily	N/A	N/A