Genome location: Pf3D7_08_v3:1,198,717..1,206,312(+)
Genome classification: Core
Product Description: SET domain protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.1.1.43 (Transferred entry: 2.1.1.354)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0034399 | nuclear periphery |
| Component | GO:0005634 | nucleus |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.78 | 0.66 |
| Trophozoite | not expressed | 1.18 | 0.44 |
| Schizont | possibly expressed | 1.20 | 0.45 |
| Gametocyte | expressed | 1.62 | 0.28 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0827800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.194 | MFS: -2.734 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0702900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBB0
"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=0.38) with 4QEN (Global RMSD=5.97)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.1.1.43 | histone-lysine N-methyltransferase | BRENDA SOAP query unsuccessful |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9H5I1 | Histone-lysine N-methyltransferase SUV39H2 | OrthoDB | US10508109, Example 1US10508109, Example 2US10508109, Example 3US10508109, Example 4... | |
| Q8X225 | Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5 | OrthoDB | chaetocin | |
| Q9Z148 | Histone-lysine N-methyltransferase EHMT2 | Mus musculus | OrthoDB | CHEMBL3933828chaetocinchaetocinchaetocin... |
| Q680I0 | E3 ubiquitin-protein ligase ORTHRUS 5 | OrthoDB | US10543221, Formula 13US10543221, Formula 14US10543221, Formula 15 | |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | OrthoDB | 2-Methoxy-N-(2-phenyl-1-(3-phenylpropyl)-1H-benzo[d]imidazol-5-yl)benzenesulfonamide (14)2-Fluoro-N-(2-phenyl-1-(3-phenylpropyl)-1H-benzo[d]imidazol-5-yl)benzamide (21)3-Bromo-N-(2-phenyl-1-(3-phenylpropyl)-1H-benzo[d]imidazol-5-yl)benzamide (22)2-Methoxy-N-(2-phenyl-1-(3-phenylpropyl)-1H-benzo[d]imidazol-5-yl)benzamide (23)... | |
| O43463 | Histone-lysine N-methyltransferase SUV39H1 | Homo sapiens | OrthoDB | CHEMBL3397332US9175331, 1CHEMBL2172426CHEMBL499593... |
| Q9H9B1 | Histone-lysine N-methyltransferase EHMT1 | Homo sapiens | OrthoDB | CHEMBL3263626UNC0224UNC0224CHEMBL569864... |
Ortholog Group (OrthoMCL): OG6_100876
Most Similar Human Ortholog: Q5JSS2
TM-align score: 0.67 | RMSD: 3.50
Seq Identity: 0.22 | Length: 134 / 2399
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101945 | suppressor of variegation 3-9 homolog 1 |
| ENSG00000119487 | MAPK associated protein 1 |
| ENSG00000152455 | suppressor of variegation 3-9 homolog 2 |
Protein Length: 2399 | Molecular Weight (kDa): 283.548
UniProt ID(s): Q8IBB0
PDB ID(s): None
Isoelectric Point: 8.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001214 | SET domain |
| InterPro | IPR015947 | PUA-like superfamily |
| PFam | PF00856 | SET domain |
| Superfamily | SSF82199 | PUA-like superfamily |
| Superfamily | SSF88697 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 31 | 119 | 75 | 157 |
| disruptive | 188 | 400 | 216 | 429 |
| missense | 110 | 282 | 176 | 305 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 53 | 237 | 98 | 169 |
| disruptive | 303 | 763 | 313 | 598 |
| missense | 166 | 546 | 236 | 365 |
PlasmoDB Total SNPs: 446
Non-coding: 52 | Synonymous: 200 | Nonsynonymous: 193 | Stop Codon: 1
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 19765590 | Potential epigenetic regulatory proteins localise to distinct nuclearsub-compartments in Plasmodium falciparum. | Volz J, Carvalho TG, ..., Cowman AF | 10.1016/j.ijpara.2009.09.002 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 32047203 | Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites. | Coetzee N, von Gruning H, ..., Birkholtz LM | 10.1038/s41598-020-59298-4 |
| 34625508 | Set4 regulates stress response genes and coordinates histone deacetylases within yeast subtelomeres | Jethmalani Y, Tran K, ..., Green EM | 10.26508/lsa.202101126 |
| 33446241 | High-resolution analysis of cell-state transitions in yeast suggests widespread transcriptional tuning by alternative starts | Chia M, Li C, ..., van Werven FJ | 10.1186/s13059-020-02245-3 |
| 34178723 | Candida albicans SET3 Plays a Role in Early Biofilm Formation, Interaction With Pseudomonas aeruginosa and Virulence in Caenorhabditis elegans | Fourie R, Albertyn J, ..., Pohl CH | 10.3389/fcimb.2021.680732 |