PF3D7_0828100

Genome location: Pf3D7_08_v3:1,211,965..1,215,795(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.07	0.97
Trophozoite	expressed	0.27	0.84
Schizont	expressed	0.06	0.96
Gametocyte	expressed	0.43	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0828100

Resistome Missense Mutations: R876K

Resistome Compounds with Missense Mutations: 3-Hydroxypropanamidine 22

Resistome # Samples with Disruptive Mutations: 2 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -2.844 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0702600)

Relative Growth Rate: 0.11 ± 0.06
Confidence: 7.12

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8A0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533236

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	57	36	76
disruptive	34	205	97	249
missense	32	194	91	227

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	119	52	92
disruptive	85	376	147	313
missense	71	344	129	244

PlasmoDB Total SNPs: 250

Non-coding: 153 | Synonymous: 53 | Nonsynonymous: 43 | Stop Codon: 1

Protein Information

Protein Length: 1033 | Molecular Weight (kDa): 124.559

UniProt ID(s): A0A5K1K8A0

PDB ID(s): None

Isoelectric Point: 9.34

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A