Genome location: Pf3D7_08_v3:1,223,542..1,226,051(-)
Genome classification: Core
Product Description: mitochondrial inner membrane protein OXA1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 4
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031305 | integral component of mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0032977 | membrane insertase activity |
| Process | GO:0033617 | mitochondrial cytochrome c oxidase assembly |
| Process | GO:0051205 | protein insertion into membrane |
| Process | GO:0032979 | protein insertion into mitochondrial inner membrane from matrix |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.25 | 0.84 |
| Schizont | expressed | 0.07 | 0.95 |
| Gametocyte | not expressed | 0.11 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0828400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.127 | MFS: -2.91 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0702300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBB5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100866
Most Similar Human Ortholog: C9JC63
TM-align score: 0.79 | RMSD: 2.53
Seq Identity: 0.20 | Length: 112 / 589
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000155463 | OXA1L mitochondrial inner membrane protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 40 | 19 | 43 |
| disruptive | 41 | 98 | 58 | 130 |
| missense | 24 | 79 | 47 | 99 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 73 | 28 | 44 |
| disruptive | 65 | 227 | 112 | 204 |
| missense | 37 | 169 | 76 | 132 |
PlasmoDB Total SNPs: 143
Non-coding: 64 | Synonymous: 38 | Nonsynonymous: 41 | Stop Codon: 0
Protein Length: 589 | Molecular Weight (kDa): 69.693
UniProt ID(s): Q8IBB5
PDB ID(s): None
Isoelectric Point: 9.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001708 | Membrane insertase YidC/ALB3/OXA1/COX18 |
| PFam | PF02096 | Membrane insertase YidC/ALB3/OXA1/COX18 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 37834108 | NMR-Based Characterization of the Interaction between Yeast Oxa1-CTD andRibosomes | Liu Y, Yang J, ..., Li Y | 10.3390/ijms241914657 |