Genome location: Pf3D7_08_v3:1,229,407..1,232,493(-)
Genome classification: Core
Product Description: folate transporter 1
SignalP Peptide: N/A
# Transmembrane Domains: 12
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0008517 | folic acid transmembrane transporter activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | possibly expressed | 0.03 | 0.98 |
| Schizont | expressed | 0.45 | 0.72 |
| Gametocyte | expressed | 0.53 | 0.70 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0828600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 1.45 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0931500)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0702400)
Modification: Disrupted | RMgm-4764
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBB7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 35 | 22 | 56 |
| disruptive | 5 | 25 | 20 | 66 |
| missense | 5 | 23 | 20 | 62 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 72 | 31 | 34 |
| disruptive | 11 | 79 | 54 | 126 |
| missense | 7 | 69 | 47 | 89 |
PlasmoDB Total SNPs: 236
Non-coding: 207 | Synonymous: 22 | Nonsynonymous: 6 | Stop Codon: 1
Protein Length: 505 | Molecular Weight (kDa): 58.06
UniProt ID(s): Q8IBB7
PDB ID(s): None
Isoelectric Point: 7.81
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR036259 | MFS transporter superfamily |
| InterPro | IPR039309 | Biopterin transporter family |
| PFam | PF03092 | Biopterin transporter family |
| Superfamily | SSF103473 | MFS transporter superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 21998306 | The molecular basis of folate salvage in Plasmodium falciparum: characterizationof two folate transporters. | Salcedo-Sora JE, Ochong E, ..., Ward SA | 10.1074/jbc.M111.286054 |