Product Description: coiled-coil domain-containing protein 39, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005930 | axoneme |
| Component | GO:0005737 | cytoplasm |
| Process | GO:0003341 | cilium movement |
| Process | GO:0060285 | cilium-dependent cell motility |
| Process | GO:0036159 | inner dynein arm assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.99 |
| Trophozoite | not expressed | 0.13 | 0.93 |
| Schizont | expressed | 1.04 | 0.48 |
| Gametocyte | expressed | 1.11 | 0.51 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0828700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.282 | #Insertions: 3
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0702000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0702000)
Modification: Disrupted | RMgm-2167
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBB8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103837
Most Similar Human Ortholog: H7C5I6
TM-align score: 0.41 | RMSD: 3.78
Seq Identity: 0.07 | Length: 45 / 1033
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000284862 | coiled-coil domain containing 39 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 73 | 38 | 64 |
| disruptive | 47 | 155 | 90 | 198 |
| missense | 37 | 147 | 84 | 177 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 28 | 118 | 60 | 84 |
| disruptive | 92 | 302 | 177 | 252 |
| missense | 66 | 263 | 150 | 199 |
PlasmoDB Total SNPs: 137
Non-coding: 42 | Synonymous: 51 | Nonsynonymous: 44 | Stop Codon: 0
Protein Length: 1033 | Molecular Weight (kDa): 123.778
UniProt ID(s): Q8IBB8
PDB ID(s): None
Isoelectric Point: 6.73
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR033290 | Coiled-coil domain-containing protein 39 |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 17653272 | Rapid identification of malaria vaccine candidates based on alpha-helical coiledcoil protein motif. | Villard V, Agak GW, ..., Corradin G | 10.1371/journal.pone.0000645 |