PF3D7_0829000

Genome location: Pf3D7_08_v3:1,244,473..1,251,543(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.38	0.81
Trophozoite	expressed	0.96	0.50
Schizont	expressed	0.76	0.58
Gametocyte	expressed	0.66	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0829000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.15 | MFS: -2.845 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBC1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533579

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	29	129	64	146
disruptive	99	437	232	455
missense	65	337	197	392

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	53	248	74	149
disruptive	208	860	317	603
missense	125	675	255	412

PlasmoDB Total SNPs: 428

Non-coding: 127 | Synonymous: 131 | Nonsynonymous: 170 | Stop Codon: 0

Protein Information

Protein Length: 1907 | Molecular Weight (kDa): 228.809

UniProt ID(s): Q8IBC1

PDB ID(s): None

Isoelectric Point: 6.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR033031	SCC2/Nipped-B family
PFam	N/A	N/A
Superfamily	N/A	N/A