Genome location: Pf3D7_08_v3:1,251,559..1,253,831(+)
Genome classification: Core
Product Description: coiled-coil domain-containing protein 124, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.27 | 0.87 |
| Trophozoite | not expressed | 0.36 | 0.77 |
| Schizont | not expressed | 0.14 | 0.90 |
| Gametocyte | possibly expressed | 0.31 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0829100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.844 | MFS: -2.326 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0701600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0701600)
Modification: Disrupted | RMgm-2166
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4Y8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102871
Most Similar Human Ortholog: M0R2F5
TM-align score: 0.45 | RMSD: 4.19
Seq Identity: 0.29 | Length: 89 / 216
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000007080 | coiled-coil domain containing 124 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 14 | 8 | 13 |
| disruptive | 0 | 8 | 11 | 29 |
| missense | 0 | 7 | 10 | 25 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 25 | 10 | 16 |
| disruptive | 0 | 38 | 42 | 58 |
| missense | 0 | 23 | 32 | 39 |
PlasmoDB Total SNPs: 129
Non-coding: 124 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 216 | Molecular Weight (kDa): 25.93
UniProt ID(s): C0H4Y8
PDB ID(s): None
Isoelectric Point: 9.96
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010422 | Coiled-coil domain-containing protein 124/Oxs1 |
| PFam | PF06244 | Coiled-coil domain-containing protein 124/Oxs1 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30208026 | Lso2 is a conserved ribosome-bound protein required for translational recovery inyeast | Wang YJ, Vaidyanathan PP, ..., Gilbert WV | 10.1371/journal.pbio.2005903 |
| 32687489 | Structure and function of yeast Lso2 and human CCDC124 bound to hibernatingribosomes | Wells JN, Buschauer R, ..., Beckmann R | 10.1371/journal.pbio.3000780 |