PF3D7_0829200 (PHB1)

Genome location: Pf3D7_08_v3:1,254,054..1,255,517(+)

Genome classification: Core

Function and Localization

Product Description: prohibitin 1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion
Function	GO:0005515	protein binding
Process	GO:0007005	mitochondrion organization
Process	GO:0042127	regulation of cell population proliferation
Process	GO:0009410	response to xenobiotic stimulus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.07	0.97
Trophozoite	expressed	0.31	0.82
Schizont	expressed	0.03	0.98
Gametocyte	expressed	0.27	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0829200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.996 | MFS: 0.867 | #Insertions: 2

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0701500)

Relative Growth Rate: 0.10 ± 0.10
Confidence: 6.03

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBC3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
O35129	Prohibitin-2		HOGENOM, OrthoDB	CHEMBL4293894

Orthology Information

Ortholog Group (OrthoMCL): OG6_101926

Most Similar Human Ortholog: E7ESE2

TM-align score: 0.89 | RMSD: 2.13

Seq Identity: 0.46 | Length: 201 / 272

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000167085	prohibitin

Protein Information

Protein Length: 272 | Molecular Weight (kDa): 30.558

UniProt ID(s): Q8IBC3

PDB ID(s): None

Isoelectric Point: 9.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000163	Prohibitin
InterPro	IPR001107	Band 7 domain
InterPro	IPR036013	Band 7/SPFH domain superfamily
PFam	PF01145	Band 7 domain
Superfamily	SSF117892	Band 7/SPFH domain superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	19	13	21
disruptive	0	2	1	10
missense	0	2	1	10

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	48	15	15
disruptive	1	11	18	60
missense	0	9	13	39

PlasmoDB Total SNPs: 96

Non-coding: 91 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0