PF3D7_0829300 (LSM8)

Genome location: Pf3D7_08_v3:1,255,816..1,257,815(+)

Genome classification: Core

Function and Localization

Product Description: U6 snRNA-associated Sm-like protein LSm8, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0046540	U4/U6 x U5 tri-snRNP complex
Component	GO:0005688	U6 snRNP
Component	GO:0071011	precatalytic spliceosome
Component	GO:0005732	sno(s)RNA-containing ribonucleoprotein complex
Function	GO:0003723	RNA binding
Function	GO:0017070	U6 snRNA binding
Process	GO:0016070	RNA metabolic process
Process	GO:0000398	mRNA splicing, via spliceosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.18	0.91
Trophozoite	expressed	0.49	0.70
Schizont	expressed	0.21	0.86
Gametocyte	expressed	0.72	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0829300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.31 | MFS: -3.211 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4Y9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102771

Most Similar Human Ortholog: F2Z2Y6

TM-align score: 0.90 | RMSD: 0.98

Seq Identity: 0.48 | Length: 63 / 95

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000128534	LSM8 homolog, U6 small nuclear RNA associated

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 160

Non-coding: 158 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 95 | Molecular Weight (kDa): 10.874

UniProt ID(s): C0H4Y9

PDB ID(s): None

Isoelectric Point: 5.61

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001163	LSM domain, eukaryotic/archaea-type
InterPro	IPR010920	LSM domain superfamily
InterPro	IPR034103	Sm-like protein Lsm8
PFam	PF01423	LSM domain, eukaryotic/archaea-type
Superfamily	SSF50182	LSM domain superfamily