PF3D7_0829500

Genome location: Pf3D7_08_v3:1,260,048..1,267,062(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.08	0.95
Schizont	not expressed	0.31	0.82
Gametocyte	not expressed	0.82	0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0829500

Resistome Missense Mutations: H447N

Resistome Compounds with Missense Mutations: 3-Hydroxypropanamidine 22

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.323 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4Z1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533755

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	22	151	73	159
disruptive	151	588	255	611
missense	93	517	230	527

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	47	284	96	165
disruptive	355	1118	409	800
missense	208	908	322	534

PlasmoDB Total SNPs: 357

Non-coding: 35 | Synonymous: 190 | Nonsynonymous: 132 | Stop Codon: 0

Protein Information

Protein Length: 2216 | Molecular Weight (kDa): 268.222

UniProt ID(s): C0H4Z1

PDB ID(s): None

Isoelectric Point: 10.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A