About Gene List

PF3D7_0830300 (SIAP2)

Genome location: Pf3D7_08_v3:1,290,240..1,291,406(-)

Genome classification: Core

Function and Localization

Product Description: sporozoite invasion-associated protein 2

SignalP Peptide: MNMYVIYYYFLILIFINSCHL

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0044164 host cell cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.04 0.98
Trophozoite not expressed 0.03 0.98
Schizont possibly expressed 0.02 0.99
Gametocyte not expressed 0.04 0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0830300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.11 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBC9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533335

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 15 7 20
disruptive 40 41 23 55
missense 37 40 19 48

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 24 14 23
disruptive 63 75 42 106
missense 53 62 37 60

PlasmoDB Total SNPs: 63

Non-coding: 0 | Synonymous: 15 | Nonsynonymous: 48 | Stop Codon: 0

Protein Information

Protein Length: 388 | Molecular Weight (kDa): 45.678

UniProt ID(s): Q8IBC9

PDB ID(s): None

Isoelectric Point: 4.5

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
23950716 Identification of new PNEPs indicates a substantial non-PEXEL exportome andunderpins common features in Plasmodium falciparum protein export. Heiber A, Kruse F, ..., Spielmann T 10.1371/journal.ppat.1003546
28089547 Antibody profiles to wheat germ cell-free system synthesized Plasmodiumfalciparum proteins correlate with protection from symptomatic malaria in Uganda Kanoi BN, Takashima E, ..., Tsuboi T 10.1016/j.vaccine.2017.01.001
34252120 Screening of viral-vectored P. falciparum pre-erythrocytic candidate vaccineantigens using chimeric rodent parasites Kolli SK, Salman AM, ..., Janse CJ 10.1371/journal.pone.0254498
22115782 3D structure and immunogenicity of Plasmodium falciparum sporozoite inducedassociated protein peptides as components of fully-protective anti-malarialvaccine Alba MP, Almonacid H, ..., Patarroyo ME 10.1016/j.bbrc.2011.11.039
38151069 Evaluating the genetic diversity of the Plasmodium vivax siap2 locus: A promisingcandidate for an effective malaria vaccine? Plata-Pineda SE, Cardenas-Munevar LX, ..., Garzon-Ospina D 10.1016/j.actatropica.2023.107111