PF3D7_0830400

Genome location: Pf3D7_08_v3:1,293,204..1,295,482(+)

Genome classification: Core

Function and Localization

Product Description: CRA domain-containing protein, putative

SignalP Peptide: MKNKLSTLFFITIFLILIFIDSAKG

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020036	Maurer's cleft

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.90	0.28
Trophozoite	expressed	1.46	0.32
Schizont	expressed	0.56	0.67
Gametocyte	expressed	0.55	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0830400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.99 | MFS: -1.825 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBD0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533412

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 122

Non-coding: 118 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 137 | Molecular Weight (kDa): 15.902

UniProt ID(s): Q8IBD0

PDB ID(s): None

Isoelectric Point: 10.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	PF06589	N/A
Superfamily	N/A	N/A