Genome location: Pf3D7_08_v3:1,295,569..1,299,431(-)
Genome classification: Core
Product Description: sporozoite and liver stage tryptophan-rich protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005783 | endoplasmic reticulum |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 2.77 | 0.17 |
| Trophozoite | not expressed | 0.58 | 0.72 |
| Schizont | possibly expressed | 0.59 | 0.69 |
| Gametocyte | not expressed | 0.29 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0830500
Resistome Missense Mutations: N465Y
Resistome Compounds with Missense Mutations: DDD01061024
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.223 | MFS: -2.668 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0524300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0524300)
Modification: Disrupted | RMgm-2048
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBD1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 31 | 17 | 21 |
| disruptive | 53 | 132 | 50 | 117 |
| missense | 43 | 97 | 39 | 80 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 55 | 17 | 37 |
| disruptive | 83 | 223 | 67 | 180 |
| missense | 59 | 165 | 41 | 119 |
PlasmoDB Total SNPs: 220
Non-coding: 101 | Synonymous: 63 | Nonsynonymous: 56 | Stop Codon: 0
Protein Length: 675 | Molecular Weight (kDa): 80.443
UniProt ID(s): Q7JN64, Q8IBD1, Q95UT5
PDB ID(s): None
Isoelectric Point: 5.99
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR022089 | Tryptophan/threonine-rich plasmodium antigen, C-terminal |
| PFam | PF12319 | Tryptophan/threonine-rich plasmodium antigen, C-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23950716 | Identification of new PNEPs indicates a substantial non-PEXEL exportome andunderpins common features in Plasmodium falciparum protein export. | Heiber A, Kruse F, ..., Spielmann T | 10.1371/journal.ppat.1003546 |
| 31476617 | A High-Resolution Map of SBP1 Interactomes in Plasmodium falciparum-infectedErythrocytes. | Takano R, Kozuka-Hata H, ..., Kato K | 10.1016/j.isci.2019.07.035 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 16329993 | Plasmodium falciparum TryThrA antigen synthetic peptides block in vitro merozoiteinvasion to erythrocytes | Curtidor H, Ocampo M, ..., Patarroyo ME | 10.1016/j.bbrc.2005.11.089 |