PF3D7_0830600

Genome location: Pf3D7_08_v3:1,301,831..1,305,620(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTc), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020036	Maurer's cleft
Process	GO:0020035	cytoadherence to microvasculature, mediated by symbiont protein

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.55	0.40
Trophozoite	not expressed	0.27	0.86
Schizont	not expressed	0.22	0.88
Gametocyte	not expressed	0.28	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0830600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.997 | MFS: -2.845 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBD2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533300

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	26	11	29
disruptive	21	49	33	70
missense	18	43	32	64

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	48	20	26
disruptive	35	108	44	94
missense	28	100	36	76

PlasmoDB Total SNPs: 147

Non-coding: 115 | Synonymous: 13 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 456 | Molecular Weight (kDa): 54.547

UniProt ID(s): Q8IBD2

PDB ID(s): None

Isoelectric Point: 4.2

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019111	Plasmodium RESA, N-terminal
PFam	PF09687	Plasmodium RESA, N-terminal
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
24983468	A Plasmodium falciparum PHIST protein binds the virulence factor PfEMP1 andcomigrates to knobs on the host cell surface.	Oberli A, Slater LM, ..., Vakonakis I	10.1096/fj.14-256057
31476617	A High-Resolution Map of SBP1 Interactomes in Plasmodium falciparum-infectedErythrocytes.	Takano R, Kozuka-Hata H, ..., Kato K	10.1016/j.isci.2019.07.035
31631203	A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum.	Das D, Krishnan SR, Roy A, Bulusu G	10.1039/c9mo00124g